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Unlike the niacinamide form of vitamin B3, the niacin form (also known as nicotinic acid), helps maintain healthy cholesterol metabolism. Niacin also improves blood circulation, especially to the peripheral parts of the body, such as the hands and feet. Niacin reduces cravings for alcohol and reduces the formation of acetaldehyde, a toxic alcohol metabolite.
Each tablet contains the following as active ingredient:
Niacin (Nicotinic Acid) 100mg
Store in a cool dry place, keep out of the reach of children.
Niacin is a precursor of nicotinamine adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which is essential for oxidation-reduction reactions, ATP synthesis, and ADP-ribose transfer reactions. At pharmacological doses niacin can decrease total cholesterol by 8% to 21%, low-density lipoprotein (LDL) cholesterol by 8% to 25%, triglycerides by 20% to 50%, and increase high-density lipoprotein (HDL) concentrations by 15% to 35%. Niacin inhibits free fatty acid release from adipose tissue; and inhibits cyclic AMP accumulation which controls the activity of triglyceride lipase and hence lipolysis. It also decreases the rate of liver synthesis of LDL and VLDL, and increases the rate of chylomicron triglyceride removal from plasma secondary to increased lipoprotein lipase activity. Niacin also causes vasodilation of cutaneous blood vessels of the face, neck and chest, mediated by prostaglandins such as prostacyclin. In most individuals, tolerance to these effects develops after about 2 weeks. Niacin may have beneficial effects on coagulation with preliminary studies indicating that niacin reduces fibrinogen levels and promote fibrinolysis in hyperlipidaemic men.
Adults and children over 12 years of age: Take 1 to 6 tablets daily, with meals. Doses as high as 20 tablets daily (2000mg) can be used, but only under the supervision of a health care provider. Niacin often causes red flushing of the skin especially when it is consumed on an empty stomach (this side effect is generally harmless).
Do not exceed recommended dosages unless on the advice of a health care provider. Do not use this product if you are allergic to any of the ingredients. If you are on any medication or suffering from any medical condition, it is advisable to seek medical advice before starting any new medicine, supplement or remedy. Safety in children has not been established.
Side effects include flushing, tingling and itching sensations as well as redness on the face, arms and chest. They are usually transient and disappear with continuous use. Other side effects are rare, but include nausea, bloating, flatulence, hunger pains, vomiting, heartburn, diarrhoea, increased sebaceous gland activity, low blood pressure, dizziness, rapid heart rate, irregular heartbeat, and blurred vision. Very high doses (greater than 3000mg (30 tablets) daily) might cause jaundice and elevated serum transaminases. Such high doses should be discontinued if liver function tests rise to three times the upper limit of normal.
There are no known contraindications.
Alcohol: Alcohol can exacerbate the flushing and pruritis associated with niacin. Allupurinol and gout medications: Large doses of niacin could potentially reduce the excretion of uric acid. Doses of uricosuric medications such as allopurinol may need to be increased. Antidiabetic medicines: Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. Carbamazepine: High doses of niacin may lead to an increase in carbamazepine blood levels. Clonidine: Concomitant use with niacin can exacerbate orthostatic hypotension in individuals prone to this condition. HMG CoA Reductase Inhibitors (statins): There is concern that niacin might increase the risk of myopathy when combined with statins. Use this combination with caution. Statin medicines include atorvastatin, fluvastatin, lovastatin, pravastatin and simvastatin.
Allergies: Niacin may exacerbate allergies by causing histamine release. Diabetes: Niacin can interfere with blood glucose requiring an adjustment of antidiabetic agents. Gout: Large amounts of niacin can precipitate gout. Peptic ulcer disease: Large amounts of niacin might activate peptic ulcer disease. Surgery: Niacin might affect blood glucose levels. Niacin may interfere with blood glucose control during and after surgery. Individuals should discontinue 2 weeks before elective surgical procedures.
Pregnancy & Breastfeeding
Not to be used by pregnant and breastfeeding women.