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Deprenyl acts as a nerve and brain cell protector. Also known as Deprenyl Citrate (please note that both the tablets and liquid we stock are the more thoroughly studied HCL version), Selegiline and Cyprenil, using Deprenyl can improve brain function, stimulate brain activity and effectively increase dopamine levels available in the brain. Used ‘off label’ to treat Alzheimer’s disease, it's recognised as one of the safest available liquids that increase dopamine and protect brain cells.
Deprenyl was originally developed as a ‘psychic energizer’, designed to integrate some amphetamine-like brain effects with anti-depressant effects. It has since been shown to protect nerve cells against a wide, and growing, number of neurotoxins, and has been shown to be a neuroprotection / neurorescue agent when nerve cells are exposed to damaging or stressful conditions. As such, liquid deprenyl has recently been appropriated as a medicine to improve brain function and neuromuscular activity. Some research centres have also noted a positive response when administering deprenyl for multiple sclerosis.
Amongst the increasingly versatile discoveries of using Deprenyl - aside from its approved use for Parkinson’s disease, its ability to improve brain function and treat Alzheimer's disease – is the effect of extending life expectancy. With the power to increase dopamine levels, this reduces cell deterioration in key parts of the brain where dopamine is transmitted – prolonging lucidity and extending life expectancy potential.
Part of a group of medicine’s known as ‘smart drugs’ – Deprenyl belongs to a class of netraceuticals that are also called Nootropics. This category of supplements work to improve brain function, facilitate faster cognitive actions and improve concentration. Nootropics are also defined as drugs that are neuroprotective, non-toxic, and posses few side effects.
The Importance of Dopamine Function and its Effect on Brain
Involved in numerous cognitive functions, dopamine plays key roles in essential activity and emotions like: movement, motivation, desire, mood, attention span, learning and working memory. Dopamine levels decrease with age and decline more steeply after the age of 40. Preserving this quantity of available dopamine is therefore essential for ensuring youthful levels of brain activity. The cyprenil mechanism of action involves inhibiting MAO-B, an enzyme that metabolizes dopamine, thus optimising available dopamine for use in the neural pathways of the brain.
Increase Dopamine Levels in Brain with Deprenyl Selegiline
The nigrostriatal tract is the tiny Dopamine serving nerve cluster in the basal ganglia – a key connector and pathway to various parts of the brain. Professor Joseph Knoll – a key scientist in establishing various brain functions - emphasised that the nigrostriatal tract typically dies off at an average rate of 13% per decade starting at around age 45. By protecting this and lowering the death rate of the neurons in the nigostriatal tract, dopamine levels could be preserved and used in the brain effectively. How this links to human longevity is in the fact that the natural rate of deterioration of the basal ganglia would mean that the human lifespan can be set at 115 years, since by that age the nigral neuron population would have dropped below 10% of its original number. At this level, death would ensue regardless of other parts of the body remaining healthy.
Professor Knoll then went on to suggest that using Deprenyl from around aged 40 (when the decline begins to become rapid ), the nigostriatal neuron death rate could be lowered and life expectancy could therefore be increased in this respect. Couple this with the increased effectiveness of brain function in later life and a direct positive effect on quality of life is attained.
In discussions of what medications increase brain function, liquid deprenyl citrate is regularly cited as one of the safest and most effective options. It has shown to be effective as l-dopa supporting agonists such as dopamine cabergoline.
Deprenyl Selegiline Usage in Treatment of Parkinsons & Alzheimer’s Disease
Deprenyl hydrochloride has become acknowledged as an effective treatment for a variety of conditions like Parkinson’s disease and increasingly as a treatment for Alzheimer’s. Deprenyl also appears to be therapeutic and ameliorative in conditions such as: cerebral infarction, a stroke, hormone inadequacy, amyotrophic lateralizing sclerosis (Lou Gehrig's disease), fatigue, chronic pain, gastric ulcers, senile dementia, sexual dysfunction, multiple sclerosis, learning difficulties, blepharospasm, hypertension, depression and cancer, and has proven extremely effective at reducing lipofuscin levels. It is also known to possess an aphrodisiac effect and helps to improve sexual function and desire.
The versatile anti-ageing smart drug
Doses are normally around 2.5mg to 5mg once, twice or three times a week, or, 1mg to 3mg per day, with regular breaks. Deprenyl liquid can be titrated (calculated) precisely as each ml drop in the bottle is equivalent to 1mg deprenyl citrate.
Deprenyl is an effective preserver of dopamine levels in the brain as well as a key cognitive enhancing smart drug – protecting nerve cells from an increasing number of neurotoxins, and providing the body with a powerful anti-ageing remedy. Deprenyl antiaging properties are well documented and a source of great interest in the scientific community.
Frequently Asked Questions About Deprenyl
Disclaimer: Please note that only your own physician can determine your precise needs, but in order to give you some information these answers are based upon the ‘average person’ and clinical/ published results.
If selegiline (deprenyl) is used in combination for old fashioned non-selective MAO inhibitors, could it theoretically prevent these medications from causing the cheese effect?
We understand that whilst there is evidence that deprenyl can prevent tyramine from entering noradrenaline using cells, that we cannot find the degree of its effectiveness, as it would be unlikely to block all the action of tyramine, and even then there would be a wide variance of criteria, including dosages that would influence the outcome.
As such, whilst it’s titration may benefit from reducing or eliminating a cheese effect for a patient, there is no clear evidence that deprenyl could be used for such a purpose. Therefore we would not recommend deprenyl being used in this way.
Can deprenyl be used with other MAO inhibitors?
There are often contraindications between different MAO inhibitors, and whilst deprenyl is a special MAO inhibitor (in that dosages under 10mg appear to only inhibit MAO-B) - it is not recommended to concurrently use deprenyl with other MAO inhibitors.
I get random drug tests and I was told that deprenyl can test positive for amphetamine metabolites, is this true?
A very high dose of deprenyl (20mg) is estimated to produce 1/100th (one hundredth) the amount of amphetamine that is required for a positive test to occur.
Dr. Dean himself was a navy surgeon and was regularly tested for drugs whilst in the service, in all that time he was taking low dose deprenyl (2-3mg per day) and never had a positive test.
It is extremely unlikely that deprenyl will produce a positive amphetamine test. Of course it is always recommended to state what medications and supplements you are taking on the form before the test is taken.
From what source is the selegiline (deprenyl) derived (organic-plant or chemical)?
Selegiline is derived via a pharmaceutical process from plant materials; I believe the original material is the Chinese herb ephedra.
I am taking 9mg of Deprenyl a day and experiencing stomach cramps, nausea and diarrhea, is the Deprenyl causing this?
Yes it could be that this relatively high dose of deprenyl is causing some of the side effects you are experiencing. Whilst we are aware that some manufacturers recommend dosages in excess of 5 mg. daily based on age, we are of the opinion that unless some forms of dementia, such as Parkinson’s is present, that there is no need to exceed an amount of 5 mg. daily.
Most preventative medicine dosages are 1 to 3 mg. daily, and we strongly recommend that dosages in excess of 5 mg. daily are built up to gradually, so for example adding an additional 1 mg. each week, providing no side effects are noted etc. It may well be possible that you can take the full 9 mg. as recommended by the manufacturer, but that for now you should reduce your dosage to say 5 mg. (or lower if necessary) and only attempt to increase this dosage as gradually as possible.
We also recommend taking occasional breaks from deprenyl use, some people prefer 1-week a month; many take deprenyl in the weekdays and none at the weekend.
Would you be so kind as to help me understand why it is that deprenyl in my case fails to raise my sex drive? Could it be that if used alone it won't raise dopamine? Is it mandatory to use B6 + DLPA along with it for one DA to be raised?
Deprenyl usually takes about 3-weeks to get to a level whereby it is enhancing dopamine levels, of course much may also depend on the dosages you are taking, you didn’t mention those or your bodyweight which can also be a factor, however we don’t normally recommend more than 5 mg. per day.
We would recommend that you read biochemist James South article here in which he states the following:
In 1991 H. Sabelli reported successful results treating 6 of 10 drug-resistant major depressive disorder patients. (9) Sabelli used 5 mg DPR daily, 100 mg vitamin B6 daily, and 1-3 grams phenylalanine twice daily as treatment. 6 of 10 patients viewed their depressive episodes terminated within 2-3 days! Global Assessment Scale scores confirmed the patients’ subjective experiences. Vitamin B6 activates the enzyme that converts phenylalanine to PEA, so the combination of low-dose DPR, B6, and phenylalanine is a bio-logical way to enhance both PEA and catecholamine brain function, and thus to diminish depression.
Therefore the addition of 100 mg vitamin B6 and 1-3 grams phenylalanine may be beneficial for libido also, and although the above study was for depression, the fact that deprenyl enhances PEA more than it enhances dopamine may be a clue to its effectiveness, as the actual process of enhancing libido is not yet fully understood.
It is not mandatory to add B6 and DLPA to deprenyl to raise dopamine levels, but that methylation (the conversion of one chemical to another in the body) varies widely from person to person and that some people will need to ensure adequate nutritional intake in the form of vitamins, enzymes and similar to have effective methylation.