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Resveratrol is a natural antioxidant found in grapes that is believed to enhance the activity of a group of genes called Sirtuins (SIRT-1). These so called ‘longevity genes’ function in protecting and repairing cells thereby enhancing cellular survival. Pterostilbene is a methylated form of resveratrol found in blueberries. Pterostilbene has the following advantages over resveratrol: better absorbed, more active and metabolised slower. Latest research indicates using both forms together is more effective than separately. Grape seed polyphenols are a source of antioxidants for the maintenance of good health.
Each capsule contains the following as active ingredients:
Grape seed extract 100mg
Store in a cool dry place below 25°C. Keep out of the reach of children.
Trans-resveratrol appears to be the primary active form of resveratrol. Resveratrol has been shown in animal and laboratory studies to exhibit antioxidant effects Preliminary research indicates that chronic administration of resveratrol can increase lifespan by activating the SIRT-1 gene and improving heart function. Grape seed extract contains phenolic compounds including oligomeric proanthrocyanidins (OPC), proanthocyanidins, flavonols and polyflavan-3-ols which have antioxidant activity. Pterostilbene is a methylated form of resveratrol which research indicate is better absorbed, metabolised at a slower rate and is pharmacologically more active.
Adults and children over 12 years of age: Take 1 capsule twice daily. Children 7-12 years of age: Take 1 capsule daily. Take with or shortly after meals.
Do not exceed recommended dosages unless on the advice of a health care provider. Do not use this product if you are allergic to any of the ingredients. If you are on any medication or suffering from any medical condition, it is advisable to seek medical advice before starting any new medicine, supplement or remedy. Safety in children has not been established.
Side effects may include dizziness, skin rash, gastrointestinal upset and headache.
Warfarin and anticoagulants: Use cautiously in patients taking anticoagulants such as warfarin, aspirin, nonsteroidal anti-inflammatory or antiplatelet agents, as OPCs may alter platelet function and aggregation Monoamine oxidase inhibitors (MAOI’s): Resveratrol competitively inhibits monoamine oxidase A and thus should be used with caution in individuals using monoamine oxidase inhibitors (MAOI’s). Cytochrome P450 3A4: Resveratrol might inhibit the cytochrome P450 3A4 enzymes and thereby increase the levels of the caffeine, chlordiazepoxide, clomipramine, clopidogrel, clozapine, diazepam, estradiol, flutamide, fluvoxamine, haloperidol, imipramine, mexiletine, mirtazapine, naproxen, nortriptyline , olanzapine, ondansetron, propafenone , propranolol, ropinirole, theophylline, verapamil, warfarin, lovastatin, ketoconazole, itraconazole, fexofenadine, triazolam, use with caution. Methotrexate: Use cautiously in individuals on methotrexate therapy due to a theoretical risk of increased methotrexate toxicity via inhibition of xanthine oxidase. ACE inhibitors: Use with caution with ACE inhibitors as can inhibit angiotensin-1 converting enzyme activity by non-competitive inhibition.
Hormone sensitive conditions: Since resveratrol may have estrogenic effects, women with hormone sensitive conditions should avoid resveratrol. Some of these conditions include breast, uterine, ovarian cancer, and endometriosis and uterine fibroids. Surgery: Discontinue use at least two weeks prior to surgery or dental procedures, due to the altered platelet function and aggregation effects.
Pregnancy & Breastfeeding
Safety in pregnancy and breastfeeding has not been established.