Acetyl-L-Carnitine & L-Carnitine - Optimal Forms - 60 capsules 700mg - Solal


 

$35.70

C299065N
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The only brand of Acetyl-L-Carnitine arginate and Propionyl-L-Carnitine in South Africa, which are more effective than any other forms of carnitine. Acetyl-L-Carnitine arginate may be the most important form of L-Carnitine in preventing brain aging, due to its high infiltration into the brain, stimulating nerve regeneration and improving their function by increasing GABA, an important brain neurotransmitter. Propionyl-L-Carnitine has a high affinity for heart muscle and helps prevent damage caused by reduced blood flow and free radicals. Propionyl-L-Carnitine also increases energy stores in the muscles, thereby assisting with chronic fatigue and exercise performance. Carnitine is also believed to improve sperm motility in men. It also enhances weight loss and fat burning in men and women.

Product Indications

Acetyl-L-carnitine arginate may be the most important form of L-carnitine in preventing brain aging, due to its high infiltration into the brain, stimulating nerve regeneration and improving their function by increasing GABA, an important brain neurotransmitter. Propionyl-l-carnitine has a high affinity for heart muscle and helps prevent damage caused by reduced blood flow and free radicals. Propionyl-L-carnitine also increases energy stores in the muscles, thereby assisting with chronic fatigue and exercise performance. Studies show that this combination also noticeably improves sexual function in men with erectile dysfunction.
 Carnitine is also known to improve sperm motility in men. It also enhances weight loss and fat burning in men and women.

Product Composition

Acetyl-L-Carnitine arginate 350mg
Propionyl-L-Carnitine 350mg

Sugar Free

Storage Instructions

Store in a cool dry place below 25°C. Keep out of the reach of children.

Pharmacological Action

Acetyl-L-carnitine is the acetylated form of L-carnitine and is superior in terms of bioavailability. The main function of acetyl-L-carnitine is the mediation of transport of long-chain fatty acids across the inner mitochondrial membrane. First, long-chain fatty acids form esters with CoA (acyl-CoA) in a reaction catalyzed by acyl-CoA synthetase (palmitoyl-CoA in the case of palmitate) in the cytoplasm. The next enzyme, carnitine palmitoyl transferase I performs transesterification by producing fatty acyl-L-carnitine esters (palmitoyl-L-carnitine) on the external surface of the inner mitochondrial membrane. This enzyme is involved in muscle physiological adaptation and results in a reduction in the oxidation of fatty acids and increased glucose utilization. Transport of the long-chain fatty acyl-L-carnitine esters across the inner mitochondrial membrane is mediated by acylcarnitine translocase, a special transport system in exchange for free L-carnitine of mitochondrial origin. On the matrix side of the inner mitochondrial membrane, carnitine palmitoyl transferase II catalyzes regeneration of long-chain acyl-CoA (palmitoyl CoA) and it is this form that subsequently undergoes β-oxidation to provide energy. In skeletal and cardiac muscle, the medium chain fatty acids with eight to 12 carbons also require carnitine for oxidation. Acetyl-L-carnitine is structurally related to acetylcholine. It also serves as a precursor to acetyl coenzyme A, and supplies acetyl groups to acetylcholine making it superior to L-carnitine in this aspect. It also seems to promote acetylcholine release and increases choline acetyltransferase activity. These effects have lead to the study of acetyl-L-carnitine in Alzheimer's disease, in which there is substantial cholinergic neuronal loss and acetylcholine depletion. It may also lessen oxidative stress and prevent oxidative damage in the brain better than L-carnitine. Carnitine levels are lower in people with complications of diabetes. In diabetic neuropathy, there is damage to sensory neuronal membranes. This causes an increase in sodium channels and therefore an increase in spontaneous neuronal firing. Acetyl-L-carnitine is thought to slow neuronal degeneration or help in the regeneration and repair of neurons and therefore decrease excessive excitability and firing. Acetyl-L-carnitine might improve peripheral as well as autonomic neuropathy. Additionally, preliminary clinical research suggests that acetyl-L-carnitine might also improve glucose utilization, possibly by increasing expression of glycolytic and gluconeogenic enzymes. Within cells, propionyl-L-carnitine helps maintain mitochondrial acyl-CoA / CoA ratios which are increased in L-carnitine deficient states, leading to deficient metabolism of fatty acids and urea synthesis. Propionyl-L-carnitine also increases pyruvate flux into the Krebs Cycle, stimulates pyruvate dehydrogenase activity, has free radical scavenging activity, improves homeostasis in the coagulation cascade, and has positive effects on blood viscosity. Compared with L-carnitine, propionyl-L-carnitine may produce greater increases in cellular L-carnitine concentrations, possibly by being transported into muscle fibers easier, and may provide additional substrates for muscle-cell energy production. Heart tissues may be able to utilize exogenous propionyl-L-carnitine to stimulate the tricarboxylic acid cycle and protect against ischemia. Intravenous and oral treatment may improve physical functioning in some people with peripheral vascular disease but a study suggesting that propionyl-L-carnitine was superior to L-carnitine in this regard used only single intravenous doses, and the clinical significance of the difference was questionable. Propionyl-L-carnitine improves energy, metabolism, and myocardial contractility in experimental models of heart failure. Small studies suggest that propionyl-L-carnitine may have a positive inotropic effect and improve ventricular function and cardiac output in chronic heart failure. It reduces myocardial ischemia, as measured by ST segment depression, in people with angina. Carnitines, including propionyl-L-carnitine, are increased by male and female sex hormones. Theoretically, propionyl-L-carnitine improves vasodilation and enhances penile blood flow, resulting in improved erectile function. Preliminary research suggests propionyl-L-carnitine might have anti-inflammatory effects, which might be responsible for its effect in Peyronie's disease.

Dosage Directions

Adults and children over 12 years of age: Take 1-2 capsules twice daily on an empty stomach, or as advised by your health care provider. Some individuals may experience a stimulating effect, therefore do not take after 4pm.

Product Warnings

Do not exceed recommended dosages unless on the advice of a health care provider. Do not use this product if you are allergic to any of the ingredients. If you are on any medication or suffering from any medical condition, it is advisable to seek medical advice before start taking any new medicine, supplement or remedy.

Side Effects

Side effects include nausea, vomiting, gastrointestinal upset and agitation.

Contraindications

There are no known contraindications.

Product Interactions

Warfarin: Use cautiously with warfarin as acetyl-L-carnitine may increase the anticoagulant effect of warfarin.

Special Precautions

Hyperthyroidism: Avoid using acetyl-L-carnitine in individuals with hypothyroidism. L-carnitine seems to inhibit the activity of the thyroid hormone in the target tissues. Theoretically, this might occur with acetyl-L-carnitine. Seizures: An increase in seizure frequency or severity has been reported in people with a history of seizures who have used L-carnitine orally or intravenously. Theoretically, this might occur with acetyl-L-carnitine.

Pregnancy & Breastfeeding

Safety in pregnancy and breastfeeding has not been established.